Endocrine Abstracts

Background: Diabetes mellitus poses a global chronic health challenge, with Tunisia experiencing a concerning surge in type 2 diabetes (T2D) prevalence. Cardiovascular and renal complications are prominent and severe consequences associated with T2D. Evaluating the costs related to managing these complications is crucial to enhance care quality, optimize resource utilization, and ultimately reduce the growing economic and social burden of this chronic disease.<p class="abs...

Introduction: The H syndrome, an autosomal recessive genodermatosis, is characterized by cutaneous and systemic manifestations resulting from mutations in the SLC29A3 gene (10q22.2), leading to histiocytic infiltration of multiple organs. This study presents a new observation of H syndrome.Observation: We report the case of a 33-year-old patient, born of consanguineous parents, with a history of diabetes diagnosed at the age of 28 and treated with oral a...

Background: Diabetes mellitus presents a pervasive global health challenge, and Tunisia grapples with a concerning upswing in the prevalence of type 2 diabetes (T2D). Cardiovascular and renal complications stand out as prevalent and severe outcomes linked to T2D. Evaluating the costs associated with managing these complications in T2D patients is pivotal for improving care quality, optimizing resource allocation, and ultimately mitigating the escalating economic and social bur...

Introduction: Multiple Endocrine Neoplasia Type 1 (MEN1) represents a rare genetic disorder characterized by a predisposition to various endocrine neoplasms, primarily affecting the parathyroid, endocrine pancreas, and pituitary gland. So far, Papillary Thyroid Carcinoma (PTC) has been detected in more than 25% of individuals bearing the MEN mutation, even though this particular cancer type does not usually belong to the clinical spectrum associated with this condition.<p ...

Introduction: Addison disease is associated with high risk of fractures and low bone mineral density. Causes are complex, including supraphysiologic glucocorticoid replacement therapy and concomitant autoimmune disorders. The aim of our study is to assess the influence of glucorticoid replacement therapy on bone mineral density in patients with Addison disease.Patients and methods: Descriptive and analytical cross- sectional study including 50 patients w...

Background and Aims: The incidence of adrenal incidentaloma(AI) has been rising sharply due to the increased use of radiologic imaging. It shows evident variation with age, with the majority of the cases presenting in the 5th to 7th decade of life. This study aims to assess the prevalence of AI and its radiological features and hormonal profiles in the geriatric population.Patients and Method: We conducted a retrospective descriptive study including 177 ...

Background and Aims: Numerous studies have suggested that metabolic syndrome (MetS) is related to adrenal incidentaloma (AI) in young adults. Limited data about MetS in geriatric patients diagnosed with AI are available, despite the high incidence of this adrenal disease in the elderly. This study aims to assess the prevalence of MetS and its associated factors in aged patients harboring AI.Patients and Method: We conducted a retrospective, comparative, ...

Introduction: In adults with Addison disease, over glucocorticoid replacement therapy is associated with an increased morbidity and decreased life expectancy, related to low bone mineral density and cardiometabolic outcomes. The aim of our study was to assess the prevalence of carbohydrate metabolism disorders in patients with Addison disease and identify its predictive factors.Patients and methods: A cross sectional study including 50 patients diagnosed...

Introduction: Long-term glucocorticoid replacement therapy in patients with Addison disease has been linked to an increased cardiovascular risk and consequent mortality. Our objective was to determine the frequency of dyslipidemia in patients with Addison disease and its potential predictive factors.Patients and methods: This was a cross-sectional study, performed in the department of endocrinology in Hedi Chaker hospital –Sfax –Tunisia. Fifty ...

Introduction: Inadequate glucocorticoid replacement therapy in Addison disease leads to an increased risk of both cardiovascular disease and metabolic syndrome. The metabolic effects of long-life corticosteroid exposure are due to physiological mechanisms that are associated with carbohydrate metabolism disorder, dyslipidemia and insulin resistance. In this study, we aimed to determine the prevalence and predictive factors of metabolic syndrome in patients with Addison disease...